Micro- and nano-patterned conductive graphene–PEG hybrid scaffolds for cardiac tissue engineering

Alec S. T. Smith; Hyok Yoo; Hyunjung Yi; Eun Hyun Ahn; Justin H. Lee; Guozheng Shao; Ekaterina Nagornyak; Michael A. Laflamme; Charles E. Murry; Deok-Ho Kim

doi:10.1039/C7CC01988B

Micro- and nano-patterned conductive graphene–PEG hybrid scaffolds for cardiac tissue engineering†

Alec S. T. Smith,

‡^afg Hyok Yoo,‡^a Hyunjung Yi,

^b Eun Hyun Ahn,

^cg Justin H. Lee,

^a Guozheng Shao,^d Ekaterina Nagornyak,^ae Michael A. Laflamme,^f Charles E. Murry

^acefg and Deok-Ho Kim

*^afg

Author affiliations

* Corresponding authors

^a Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
E-mail: deokho@uw.edu

^b Post-Silicon Semiconductor Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea

^c Department of Pathology, University of Washington, Seattle, WA 98195, USA

^d Department of Chemistry, University of Washington, Seattle, WA 98195, USA

^e Department of Medicine/Cardiology, University of Washington, Seattle, WA 98195, USA

^f Center for Cardiovascular Biology, University of Washington, Seattle, WA 98195, USA

^g Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA

Abstract

A lack of electrical conductivity and structural organization in currently available biomaterial scaffolds limits their utility for generating physiologically representative models of functional cardiac tissue. Here we report on the development of scalable, graphene-functionalized topographies with anisotropic electrical conductivity for engineering the structural and functional phenotypes of macroscopic cardiac tissue constructs. Guided by anisotropic electroconductive and topographic cues, the tissue constructs displayed structural property enhancement in myofibrils and sarcomeres, and exhibited significant increases in the expression of cell–cell coupling and calcium handling proteins, as well as in action potential duration and peak calcium release.

This article is part of the themed collection: 2017 Emerging Investigators

Chemical Communications

Micro- and nano-patterned conductive graphene–PEG hybrid scaffolds for cardiac tissue engineering†

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Micro- and nano-patterned conductive graphene–PEG hybrid scaffolds for cardiac tissue engineering

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