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Issue 6, 2016
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Alteration of mitochondrial phospholipid due to the PLA2 activation in rat brains under cadmium toxicity

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Abstract

Cadmium (Cd) is a heavy metal that has received considerable environmental and occupational concern. Cd causes toxic effects due to its accumulation in a variety of tissues, including the kidney, liver and the nervous system (CNS); however, the exact mechanism is poorly understood. In the present study, we tried to explore the impact of acute cadmium exposure on rat brain phospholipids (PLs). Cd exposure significantly reduced PLs in a time dependent manner and the reduction was due to the activation of the Phospholipase A2 enzymes (sPLA2, cPLA2). The release of arachidonic acid from PLs increased during inflammatory conditions by PLA2s. The mRNA expression of cyclooxygenase2 (COX2) and subsequently the pro-inflammatory cytokines, namely, Interleukin 1 (IL-1) and IL-6, were up regulated; however, the expression of anti-inflammatory cytokine IL-10 was reduced in a time dependent manner. The expression of the Tumor necrosis factor alpha (TNF-α), Inducible nitric oxide synthase (iNOS) and Interferon gamma (INF-γ) also experienced increases in the expression. Likewise the mRNA expression of the pro-apoptotic factor, Bcl-2-associated X protein (Bax), was elevated, whereas anti-apoptosis B-cell lymphoma 2 (Bcl2) was down regulated. This present study might help to decipher the effects of cadmium toxicity on rat brain.

Graphical abstract: Alteration of mitochondrial phospholipid due to the PLA2 activation in rat brains under cadmium toxicity

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Publication details

The article was received on 11 May 2016, accepted on 12 Sep 2016 and first published on 03 Oct 2016


Article type: Paper
DOI: 10.1039/C6TX00201C
Citation: Toxicol. Res., 2016,5, 1680-1687
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    Alteration of mitochondrial phospholipid due to the PLA2 activation in rat brains under cadmium toxicity

    C. Sivaprakasam, R. Vijayakumar, M. Arul and V. Nachiappan, Toxicol. Res., 2016, 5, 1680
    DOI: 10.1039/C6TX00201C

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