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Issue 45, 2016
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Protease-sensitive atelocollagen hydrogels promote healing in a diabetic wound model

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Abstract

The design of exudate-managing wound dressings is an established route to accelerated healing, although such design remains a challenge from material and manufacturing standpoints. Aiming towards the clinical translation of knowledge gained in vitro with highly-swollen rat tail collagen hydrogels, this study investigated the healing capability in a diabetic mouse wound model of telopeptide-free, protease-inhibiting collagen networks. 4-Vinylbenzylation and UV irradiation of type I atelocollagen (AC) led to hydrogel networks with chemical and macroscopic properties comparable to previous collagen analogues, attributable to similar lysine content and dichroic properties. After 4 days in vitro, hydrogels induced nearly 50 RFU% reduction in matrix metalloproteinase (MMP)-9 activity, whilst showing less than 20 wt% mass loss. After 20 days in vivo, dry networks promoted 99% closure of 10 × 10 mm full thickness wounds and accelerated neo-dermal tissue formation compared to Mepilex®. This collagen system can be equipped with multiple, customisable properties and functions key to personalised chronic wound care.

Graphical abstract: Protease-sensitive atelocollagen hydrogels promote healing in a diabetic wound model

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Publication details

The article was received on 02 Sep 2016, accepted on 17 Oct 2016 and first published on 18 Oct 2016


Article type: Paper
DOI: 10.1039/C6TB02268E
Citation: J. Mater. Chem. B, 2016,4, 7249-7258
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    Protease-sensitive atelocollagen hydrogels promote healing in a diabetic wound model

    G. Tronci, J. Yin, R. A. Holmes, H. Liang, S. J. Russell and D. J. Wood, J. Mater. Chem. B, 2016, 4, 7249
    DOI: 10.1039/C6TB02268E

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