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Issue 45, 2016
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Ultrabright organic fluorescent microparticles for in vivo tracing applications

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Abstract

We report the in vivo distribution, toxicity and metabolism of micro-sized fluorescent organic particles and their applications in cerebral blood flow tracing. The fluorescent microparticles exhibit bright fluorescence, good photo-stability and low toxicity; therefore, they are ideal for long-term non-invasive in vivo tracing. In contrast to conventional fluorescent labeling agents, which stain the entire blood vessel, the tracer microparticles can be easily tracked individually and provide vital information about blood flow behavior. Furthermore, we observed stimulated emission from these microparticles in living animals. These microparticles can provide unprecedented contrast for simultaneous observation of the distribution of blood vessels and the dynamics of microcirculation. Pathological examination revealed that the injected microparticles eventually collected in the spleen and liver. We found no observable toxicity of the microparticles to cells or mouse organs. We demonstrate that these fluorescent microparticles are suitable for applications in the field of non-intrusive blood flow tracing and could play a complementary role to traditional imaging agents.

Graphical abstract: Ultrabright organic fluorescent microparticles for in vivo tracing applications

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Publication details

The article was received on 15 Jul 2016, accepted on 17 Oct 2016, published on 18 Oct 2016 and first published online on 18 Oct 2016


Article type: Paper
DOI: 10.1039/C6TB01782G
Citation: J. Mater. Chem. B, 2016,4, 7226-7232
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    Ultrabright organic fluorescent microparticles for in vivo tracing applications

    C. Sun, T. Li, J. Jiang, J. Li, D. Jiang, J. Cao, S. Zhang and H. Zhang, J. Mater. Chem. B, 2016, 4, 7226
    DOI: 10.1039/C6TB01782G

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