Jump to main content
Jump to site search

Issue 43, 2016
Previous Article Next Article

Hollow mesoporous carbon nanocarriers for vancomycin delivery: understanding the structure–release relationship for prolonged antibacterial performance

Author affiliations

Abstract

Mono-dispersed mesoporous hollow carbon (MHC) nanospheres with comparable structures have been designed as nanocarriers for the delivery of vancomycin (Van) to inhibit bacterial growth. It is demonstrated that MHC materials possess a Van loading capacity of 861 mg g−1, much higher than that of any Van nanocarrier in previous reports. By comparing the drug loading, release and antibacterial performance of MHC nanospheres with controllable structures, it is shown that MHC with a pore size of 5.8 nm and a wall thickness of 25 nm exhibits compromising storage–release behaviour and achieves extended bactericidal activity of Van towards E. coli and S. epidermidis compared to free Van and other MHC nanocarriers. This study provides new knowledge about the rational design of carbon based nanocarriers to enhance the therapeutic efficacy of antibiotics.

Graphical abstract: Hollow mesoporous carbon nanocarriers for vancomycin delivery: understanding the structure–release relationship for prolonged antibacterial performance

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 15 Jul 2016, accepted on 03 Oct 2016, published on 04 Oct 2016 and first published online on 04 Oct 2016


Article type: Paper
DOI: 10.1039/C6TB01778A
Citation: J. Mater. Chem. B, 2016,4, 7014-7021
  •   Request permissions

    Hollow mesoporous carbon nanocarriers for vancomycin delivery: understanding the structure–release relationship for prolonged antibacterial performance

    Y. Ahmad Nor, H. Zhang, S. Purwajanti, H. Song, A. K. Meka, Y. Wang, N. Mitter, D. Mahony and C. Yu, J. Mater. Chem. B, 2016, 4, 7014
    DOI: 10.1039/C6TB01778A

Search articles by author