Issue 42, 2016
From the journal:

Journal of Materials Chemistry B

A redox-responsive theranostic agent for target-specific fluorescence imaging and photodynamic therapy of EGFR-overexpressing triple-negative breast cancers†

Jisu Kim,a   Youngjae Won,b   Sung-Ho Gohc  and  Yongdoo Choi*ac  

* Corresponding authors

a Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10408, Republic of Korea
E-mail: ydchoi@ncc.re.kr
Fax: +82-31-920-2630
Tel: +82-31-920-2512

b Medical Device Development Center, Osong Medical Innovation Foundation, Cheongju-si, Chungbuk 28160, Republic of Korea

c Precision Medicine Branch, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10408, Republic of Korea

Abstract

A redox-responsive specific theranostic agent was developed by the conjugation of photosensitizers with the tryptophan-containing GE11 peptide via a cleavable disulfide linker. It showed a potential utility for the target-cell-specific activatable fluorescence imaging and photodynamic therapy of triple-negative breast cancers.

Graphical abstract: A redox-responsive theranostic agent for target-specific fluorescence imaging and photodynamic therapy of EGFR-overexpressing triple-negative breast cancers

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C6TB01519K
Article type
Communication
Submitted
20 Jun 2016
Accepted
11 Sep 2016
First published
13 Sep 2016

J. Mater. Chem. B, 2016,4, 6787-6790

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A redox-responsive theranostic agent for target-specific fluorescence imaging and photodynamic therapy of EGFR-overexpressing triple-negative breast cancers

J. Kim, Y. Won, S. Goh and Y. Choi, J. Mater. Chem. B, 2016, 4, 6787 DOI: 10.1039/C6TB01519K

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