Issue 35, 2016
From the journal:

Journal of Materials Chemistry B

Delivery of an active lysosomal enzyme using GNeosomes†

Kristina M. Hamill,a   Ezequiel Wexselblatt,a   Wenyong Tong,b   Jeffrey D. Eskob  and  Yitzhak Tor*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA
E-mail: ytor@ucsd.edu

b Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA

Abstract

Two methods for assembling guanidinoneomycin-decorated liposomes are presented and their ability to deliver an active enzyme to the lysosomes and restore enzyme function in diseased cells is compared.

Graphical abstract: Delivery of an active lysosomal enzyme using GNeosomes

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Article information

DOI
https://doi.org/10.1039/C6TB01387B
Article type
Communication
Submitted
03 Jun 2016
Accepted
09 Aug 2016
First published
09 Aug 2016
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2016,4, 5794-5797

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Delivery of an active lysosomal enzyme using GNeosomes

K. M. Hamill, E. Wexselblatt, W. Tong, J. D. Esko and Y. Tor, J. Mater. Chem. B, 2016, 4, 5794 DOI: 10.1039/C6TB01387B

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