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Issue 32, 2016
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Fortified interpenetrating polymers – bacteria resistant coatings for medical devices

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Abstract

Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical device-associated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-bound Klebsiella pneumoniae and methicillin resistant Staphylococcus aureus.

Graphical abstract: Fortified interpenetrating polymers – bacteria resistant coatings for medical devices

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Publication details

The article was received on 04 May 2016, accepted on 15 Jul 2016 and first published on 18 Jul 2016


Article type: Paper
DOI: 10.1039/C6TB01110A
Citation: J. Mater. Chem. B, 2016,4, 5405-5411
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    Fortified interpenetrating polymers – bacteria resistant coatings for medical devices

    S. Venkateswaran, O. D. Henrique Dos Santos, E. Scholefield, A. Lilienkampf, P. J. Gwynne, D. G. Swann, K. Dhaliwal, M. P. Gallagher and M. Bradley, J. Mater. Chem. B, 2016, 4, 5405
    DOI: 10.1039/C6TB01110A

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