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Issue 9, 2016
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On-demand, magnetic hyperthermia-triggered drug delivery: optimisation for the GI tract

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Abstract

An orally-administered vehicle for targeted, on-demand drug delivery to the gastrointestinal (GI) tract is highly desirable due to the high incidence of diseases of that organ system and harsh mechanical and physical conditions any such drug delivery vehicle has to endure. To that end, we present an iron oxide nanoparticle/wax composite capsule coating that protects the capsule contents from the highly variable chemical conditions of the GI tract. It can be triggered using magnetic hyperthermia initiated from an external AC magnetic field. The coating is produced from pharmaceutically approved materials and is applied using a simple dip-coating process using a gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions found within the GI tract, but is completely melted within two minutes of magnetically-induced heating under biologically-relevant conditions of temperature, pH, buffer and external field strength, allowing the delivery and dispersal of the capsule contents. The overall simplicity of action, durability and non-toxic and inexpensive nature of our drug delivery vehicle demonstrated herein are key for successful drug delivery systems for the kinds of focal therapy being sought for modern precision medicine.

Graphical abstract: On-demand, magnetic hyperthermia-triggered drug delivery: optimisation for the GI tract

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Publication details

The article was received on 05 Oct 2015, accepted on 01 Feb 2016 and first published on 02 Feb 2016


Article type: Paper
DOI: 10.1039/C5TB02068A
Author version available: Download Author version (PDF)
Citation: J. Mater. Chem. B, 2016,4, 1704-1711
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    On-demand, magnetic hyperthermia-triggered drug delivery: optimisation for the GI tract

    L. Che Rose, J. C. Bear, P. Southern, P. D. McNaughter, R. B. Piggott, I. P. Parkin, S. Qi, B. P. Hills and A. G. Mayes, J. Mater. Chem. B, 2016, 4, 1704
    DOI: 10.1039/C5TB02068A

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