Jump to main content
Jump to site search

Issue 6, 2016
Previous Article Next Article

Synthesis, characterization, antibacterial activity and cytotoxicity of hollow TiO2-coated CeO2 nanocontainers encapsulating silver nanoparticles for controlled silver release

Author affiliations

Abstract

Biomaterials as implants are being applied more extensively in medicine due to their on-going development and associated improvements, and the increase in human life expectancy. Nonetheless, biomaterial-related infections, as well as propagating bacterial resistance, remain significant issues. Therefore, there is a growing interest for silver-based drugs because of their efficient and broad-range antimicrobial activity and low toxicity to humans. Most newly-developed silver-based drugs have an extremely fast silver-ion release, increasing adverse biological impact to the surrounding tissue and achieving only short-term antimicrobial activity. Nanoencapsulation of these drugs is hypothesized as beneficial for controlling silver release, and thus is the aim of the present study. Initially, an amorphous or crystalline (anatase) titania (TiO2) coating was synthesized around silver nanoparticle-containing (AgNP) ceria (CeO2) nanocontainers using a sonication method forming AgNP/CeO2/TiO2 nanocontainers. These nanocontainers were characterized by high-resolution transmission electron microscopy, scanning electron microscopy, powder X-ray diffraction, gas sorption experiments and energy-dispersive X-ray spectroscopy. Silver release, monitored by using inductively coupled plasma optical emission spectroscopy, showed that these containers prevented silver release in water at neutral pH, and released the silver in concentrated nitric acid solution (pH = 1.1). The AgNP/CeO2/TiO2 nanocontainers showed an antibacterial activity against E. coli, however a concentration-dependent cytotoxicity towards a model epithelial barrier cell type (A549 cells) was observed. These nanocontainers offer the concept of potentially controlling silver delivery for the prevention of implant-associated infections.

Graphical abstract: Synthesis, characterization, antibacterial activity and cytotoxicity of hollow TiO2-coated CeO2 nanocontainers encapsulating silver nanoparticles for controlled silver release

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 Sep 2015, accepted on 06 Jan 2016 and first published on 14 Jan 2016


Article type: Paper
DOI: 10.1039/C5TB01917F
Author version
available:
Download author version (PDF)
Citation: J. Mater. Chem. B, 2016,4, 1166-1174
  •   Request permissions

    Synthesis, characterization, antibacterial activity and cytotoxicity of hollow TiO2-coated CeO2 nanocontainers encapsulating silver nanoparticles for controlled silver release

    J. Gagnon, M. J. D. Clift, D. Vanhecke, I. E. Widnersson, S.-L. Abram, A. Petri-Fink, R. A. Caruso, B. Rothen-Rutishauser and K. M. Fromm, J. Mater. Chem. B, 2016, 4, 1166
    DOI: 10.1039/C5TB01917F

Search articles by author

Spotlight

Advertisements