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Issue 1, 2017
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Clogging of microfluidic systems

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Abstract

The transport of suspensions of microparticles in confined environments is associated with complex phenomena at the interface of fluid mechanics and soft matter. Indeed, the deposition and assembly of particles under flow involve hydrodynamic, steric and colloidal forces, and can lead to the clogging of microchannels. The formation of clogs dramatically alters the performance of both natural and engineered systems, effectively limiting the use of microfluidic technology. While the fouling of porous filters has been studied at the macroscopic level, it is only recently that the formation of clogs has been considered at the pore-scale, using microfluidic devices. In this review, we present the clogging mechanisms recently reported for suspension flows of colloidal particles and for biofluids in microfluidic channels, including sieving, bridging and aggregation of particles. We discuss the technological implications of the clogging of microchannels and the schemes that leverage the formation of clogs. We finally consider some of the outstanding challenges involving clogging in human health, which could be tackled with microfluidic methods.

Graphical abstract: Clogging of microfluidic systems

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Publication details

The article was received on 14 Aug 2016, accepted on 18 Oct 2016 and first published on 18 Oct 2016


Article type: Review Article
DOI: 10.1039/C6SM01879C
Citation: Soft Matter, 2017,13, 37-48
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    Clogging of microfluidic systems

    E. Dressaire and A. Sauret, Soft Matter, 2017, 13, 37
    DOI: 10.1039/C6SM01879C

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