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Issue 43, 2016
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Developing a self-healing supramolecular nucleoside hydrogel

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Abstract

Low molecular weight gelator hydrogels provide a viable alternative to traditional polymer based drug delivery platforms, owing to their tunable stability and in most cases inherent biocompatibility. Here we report the first self-healing nucleoside hydrogel using N4-octanoyl-2′-deoxycytidine (0.5% w/v) for drug delivery. The hydrogel's cross-linked nanofibrillar structure, was characterised using oscillatory rheology and confirmed using SEM and TEM imaging. The potential of this gel for drug delivery was explored in vitro using fluorescently labelled tracers. Cell viability assays were conducted using pancreatic cell lines which tolerated the gels well; whilst no adverse effects on the viability or proliferation of cells were observed for fibroblast cell lines.

Graphical abstract: Developing a self-healing supramolecular nucleoside hydrogel

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Publication details

The article was received on 02 Aug 2016, accepted on 19 Sep 2016 and first published on 21 Sep 2016


Article type: Paper
DOI: 10.1039/C6SM01779G
Citation: Soft Matter, 2016,12, 8950-8957
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    Developing a self-healing supramolecular nucleoside hydrogel

    K. J. Skilling, B. Kellam, M. Ashford, T. D. Bradshaw and M. Marlow, Soft Matter, 2016, 12, 8950
    DOI: 10.1039/C6SM01779G

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