Jump to main content
Jump to site search

Issue 44, 2016
Previous Article Next Article

Micelle response to changes in solvent properties

Author affiliations

Abstract

The dynamics of co-polymer systems play an important role in the preparation and stability of formulations, as well as on their capability to function in drug delivery systems. Micelle inversion can occur as a result of a change in concentration when a solvent is very volatile and evaporates, or as a result of a change in solvent quality upon addition of another solvent to the original solution, or upon changes in pH. In this work, dissipative particle dynamics (DPD) is used to examine the dynamics of micelle inversion in concentrated systems of diblock and triblock amphiphiles, where interactions between neighboring aggregates are observed. Significant differences were observed in the inversion process of different amphiphilic molecules, with a large amount of co-polymer exchange between inverting aggregates made of diblock amphiphiles, and practically no exchange of molecules between aggregates during the inversion of triblock copolymer aggregates. Fundamental mechanisms of inversion are revealed that provide information which can be used to help design micelles for targeted drug release and allow understanding of history dependant formulations.

Graphical abstract: Micelle response to changes in solvent properties

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 01 Aug 2016, accepted on 14 Oct 2016 and first published on 14 Oct 2016


Article type: Paper
DOI: 10.1039/C6SM01761D
Citation: Soft Matter, 2016,12, 9014-9024
  •   Request permissions

    Micelle response to changes in solvent properties

    T. L. Rodgers, J. E. Magee, T. Amure and F. R. Siperstein, Soft Matter, 2016, 12, 9014
    DOI: 10.1039/C6SM01761D

Search articles by author