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Issue 1, 2017
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Sticking and sliding of lipid bilayers on deformable substrates

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Abstract

We examine here the properties of lipid bilayers coupled to deformable substrates. We show that by changing the extent of the substrate hydrophilicity, we can control the membrane–substrate coupling and the response of the bilayer to strain deformation. Our results demonstrate that lipid bilayers coupled to flexible substrates can easily accommodate large strains, form stable protrusions and open reversibly pores. These properties, which differ significantly from those of free standing membranes, can extend the applications of the current lipid technologies. Moreover, such systems better capture the mechanical architecture of the cell interface and can provide insights into the capacity of cells to reshape and respond to mechanical perturbations.

Graphical abstract: Sticking and sliding of lipid bilayers on deformable substrates

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Publication details

The article was received on 31 Mar 2016, accepted on 10 Jun 2016 and first published on 13 Jun 2016


Article type: Paper
DOI: 10.1039/C6SM00786D
Citation: Soft Matter, 2017,13, 181-186
  • Open access: Creative Commons BY license
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    Sticking and sliding of lipid bilayers on deformable substrates

    L. Stubbington, M. Arroyo and M. Staykova, Soft Matter, 2017, 13, 181
    DOI: 10.1039/C6SM00786D

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