Jump to main content
Jump to site search

Issue 2, 2017
Previous Article Next Article

Harnessing non-covalent interactions to exert control over regioselectivity and site-selectivity in catalytic reactions

Author affiliations

Abstract

Asymmetric catalysis has been revolutionised by the realisation that attractive non-covalent interactions such as hydrogen bonds and ion pairs can act as powerful controllers of enantioselectivity when incorporated into appropriate small molecule chiral scaffolds. Given these tremendous advances it is surprising that there are still a relatively limited number of examples of non-covalent interactions being harnessed for control of regioselectivity or site-selectivity in catalysis, two other fundamental selectivity aspects facing the synthetic chemist. This perspective examines the progress that has been made in this area thus far using non-covalent interactions in conjunction with transition metal catalysis as well as in the context of purely organic catalysts. We hope this will highlight the great potential in this approach for designing selective catalytic reactions.

Graphical abstract: Harnessing non-covalent interactions to exert control over regioselectivity and site-selectivity in catalytic reactions

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 16 Sep 2016, accepted on 05 Oct 2016 and first published on 05 Oct 2016


Article type: Perspective
DOI: 10.1039/C6SC04157D
Citation: Chem. Sci., 2017,8, 864-877
  • Open access: Creative Commons BY license
  •   Request permissions

    Harnessing non-covalent interactions to exert control over regioselectivity and site-selectivity in catalytic reactions

    H. J. Davis and R. J. Phipps, Chem. Sci., 2017, 8, 864
    DOI: 10.1039/C6SC04157D

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author