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Issue 2, 2017
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Palladium(0)-catalyzed asymmetric C(sp3)–H arylation using a chiral binol-derived phosphate and an achiral ligand

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Abstract

The first efficient palladium(0)-catalyzed enantioselective C(sp3)–H activation reaction using a catalytic chiral base and an achiral phosphine ligand is reported. Fine-tuning the binol-derived phosphoric acid pre-catalyst and the reaction conditions was found to be crucial to achieve high levels of enantioselectivity for a variety of indoline products containing both tri- and tetrasubstituted stereocenters.

Graphical abstract: Palladium(0)-catalyzed asymmetric C(sp3)–H arylation using a chiral binol-derived phosphate and an achiral ligand

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Publication details

The article was received on 07 Sep 2016, accepted on 08 Oct 2016 and first published on 11 Oct 2016


Article type: Edge Article
DOI: 10.1039/C6SC04006C
Citation: Chem. Sci., 2017,8, 1344-1349
  • Open access: Creative Commons BY-NC license
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    Palladium(0)-catalyzed asymmetric C(sp3)–H arylation using a chiral binol-derived phosphate and an achiral ligand

    L. Yang, R. Melot, M. Neuburger and O. Baudoin, Chem. Sci., 2017, 8, 1344
    DOI: 10.1039/C6SC04006C

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