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Issue 2, 2017
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Integration of aerobic oxidation and intramolecular asymmetric aza-Friedel–Crafts reactions with a chiral bifunctional heterogeneous catalyst

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Abstract

A new class of chiral bifunctional heterogeneous materials composed of Au/Pd nanoparticles and chiral phosphoric acids as active orthogonal catalysts was prepared by utilizing a facile pseudo-suspension co-polymerization method. It was found that this heterogeneous catalyst was capable of facilitating the sequential aerobic oxidation-asymmetric intramolecular aza-Friedel–Crafts reaction between benzyl alcohols and N-aminoethylpyrroles. Moreover, the designed chiral heterogeneous catalyst could be recovered and reused several times without significant loss of activity or enantioselectivity.

Graphical abstract: Integration of aerobic oxidation and intramolecular asymmetric aza-Friedel–Crafts reactions with a chiral bifunctional heterogeneous catalyst

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Publication details

The article was received on 28 Aug 2016, accepted on 05 Oct 2016, published on 05 Oct 2016 and first published online on 05 Oct 2016


Article type: Edge Article
DOI: 10.1039/C6SC03849B
Citation: Chem. Sci., 2017,8, 1356-1359
  • Open access: Creative Commons BY license
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    Integration of aerobic oxidation and intramolecular asymmetric aza-Friedel–Crafts reactions with a chiral bifunctional heterogeneous catalyst

    H. Cheng, J. Miguélez, H. Miyamura, W. Yoo and S. Kobayashi, Chem. Sci., 2017, 8, 1356
    DOI: 10.1039/C6SC03849B

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