Issue 2, 2017

Chemical optogenetic modulation of inflammation and immunity

Abstract

The immune system is an essential component of host defense against pathogens and is largely mediated by inflammatory molecules produced by immune cells, such as macrophages. These inflammatory mediators are regulated at the transcriptional level by chromatin-modifying enzymes including histone deacetylases (HDACs). Here we describe a strategy to regulate inflammation and immunity with photocontrolled HDAC inhibitors, which can be selectively delivered to target cells by UV irradiation to minimize off-target effects. We strategically photocaged the active moiety of an HDAC inhibitor and showed that mild UV irradiation leads to the selective release of the inhibitor in a spatiotemporal manner. This methodology was used to decrease the amount of pro-inflammatory mediators produced by a subpopulation of macrophages. Our approach could ultimately be used to control inflammation in vivo as a therapeutic for inflammatory diseases, while minimizing off-target effects to healthy tissues.

Graphical abstract: Chemical optogenetic modulation of inflammation and immunity

Supplementary files

Article information

Article type
Edge Article
Submitted
17 Aug 2016
Accepted
19 Oct 2016
First published
21 Oct 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2017,8, 1450-1453

Chemical optogenetic modulation of inflammation and immunity

B. Parasar and P. V. Chang, Chem. Sci., 2017, 8, 1450 DOI: 10.1039/C6SC03702J

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