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Issue 3, 2017
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Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

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Abstract

The generation of antibody conjugates with a loading of two modules is desirable for a host of reasons. Whilst certain antibody engineering approaches have been useful in the preparation of such constructs, a reliable method based on a native antibody scaffold without the use of enzymes or harsh oxidative conditions has hitherto not been achieved. The use of native antibodies has several advantages in terms of cost, practicality, accessibility, time and overall efficiency. Herein we present a novel, reliable method of furnishing antibody conjugates with a loading of two modules starting from a native antibody scaffold.

Graphical abstract: Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

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Publication details

The article was received on 15 Aug 2016, accepted on 24 Nov 2016 and first published on 28 Nov 2016


Article type: Edge Article
DOI: 10.1039/C6SC03655D
Citation: Chem. Sci., 2017,8, 2056-2060
  • Open access: Creative Commons BY license
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    Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

    M. T. W. Lee, A. Maruani, D. A. Richards, J. R. Baker, S. Caddick and V. Chudasama, Chem. Sci., 2017, 8, 2056
    DOI: 10.1039/C6SC03655D

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