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Issue 1, 2017
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Total synthesis of malagashanine: a chloroquine potentiating indole alkaloid with unusual stereochemistry

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Abstract

The first total synthesis of malagashanine, a chloroquine potentiating indole alkaloid, is presented. A highly stereoselective cascade annulation reaction was developed to generate the tetracyclic core of the Malagasy alkaloids. This chemistry is likely to be broadly applicable to the synthesis of other members of this stereochemically unique family of natural products.

Graphical abstract: Total synthesis of malagashanine: a chloroquine potentiating indole alkaloid with unusual stereochemistry

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The article was received on 10 Aug 2016, accepted on 11 Sep 2016 and first published on 19 Sep 2016


Article type: Edge Article
DOI: 10.1039/C6SC03578G
Citation: Chem. Sci., 2017,8, 697-700
  • Open access: Creative Commons BY license
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    Total synthesis of malagashanine: a chloroquine potentiating indole alkaloid with unusual stereochemistry

    A. Kong, D. E. Mancheno, N. Boudet, R. Delgado, E. S. Andreansky and S. B. Blakey, Chem. Sci., 2017, 8, 697
    DOI: 10.1039/C6SC03578G

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