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Issue 1, 2017
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Ru-catalyzed sequence for the synthesis of cyclic amido-ethers

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Abstract

Efficient synthesis of versatile building blocks for enabling medicinal chemistry research has always challenged synthetic chemists to develop innovative methods. Of particular interest are the methods that are amenable to the synthesis of chemically distinct and diverse classes of pharmaceutically relevant motifs. Herein we report a general method for the one-pot synthesis of cyclic α-amido-ethers containing different amide functionalities including lactams, tetramic acids and amino acids. For the incorporation of the nucleotide bases, a chemo and regioselective palladium-catalyzed transformation has been developed, providing rapid access to nucleoside analogs.

Graphical abstract: Ru-catalyzed sequence for the synthesis of cyclic amido-ethers

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Publication details

The article was received on 27 Jun 2016, accepted on 11 Sep 2016, published on 12 Sep 2016 and first published online on 12 Sep 2016


Article type: Edge Article
DOI: 10.1039/C6SC02849G
Citation: Chem. Sci., 2017,8, 770-774
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    Ru-catalyzed sequence for the synthesis of cyclic amido-ethers

    B. M. Trost, E. U. Sharif and J. J. Cregg, Chem. Sci., 2017, 8, 770
    DOI: 10.1039/C6SC02849G

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