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Issue 1, 2017
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Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes

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Abstract

Suzuki–Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.

Graphical abstract: Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes

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Publication details

The article was received on 13 May 2016, accepted on 04 Aug 2016 and first published on 09 Aug 2016


Article type: Perspective
DOI: 10.1039/C6SC02118B
Citation: Chem. Sci., 2017,8, 40-62
  • Open access: Creative Commons BY-NC license
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    Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes

    J. Almond-Thynne, D. C. Blakemore, D. C. Pryde and A. C. Spivey, Chem. Sci., 2017, 8, 40
    DOI: 10.1039/C6SC02118B

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