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Edge Article

Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics

Corresponding authors
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
E-mail: wqchen@whu.edu.cn
CAS Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 300 FengLin Road, Shanghai 200032, China
E-mail: ylxiao@sibs.ac.cn
University of Chinese Academy of Sciences, Beijing 100039, China
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Chem. Sci., 2017,8, 444-451

DOI: 10.1039/C6SC01826B
Received 26 Apr 2016, Accepted 17 Aug 2016
First published online 19 Aug 2016
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Open Access
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Supplementary Info