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Issue 7, 2016
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Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents

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Abstract

A Gd3+-coordinated polymerizable analogue of the MRI contrast agent Gd-DOTA was used to prepare amphiphilic block copolymers, with hydrophilic blocks composed entirely of the polymerized contrast agent. The resulting amphiphilic block copolymers assemble into nanoparticles (NPs) of spherical- or fibril-shape, each demonstrating enhanced relaxivity over Gd-DOTA. As an initial examination of their behavior in vivo, intraperitoneal (IP) injection of NPs into live mice was performed, showing long IP residence times, observed by MRI. Extended residence times for particles of well-defined morphology may represent a valuable design paradigm for treatment or diagnosis of peritoneal malignances.

Graphical abstract: Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents

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Publication details

The article was received on 23 Jan 2016, accepted on 03 Mar 2016 and first published on 22 Mar 2016


Article type: Edge Article
DOI: 10.1039/C6SC00342G
Citation: Chem. Sci., 2016,7, 4230-4236
  • Open access: Creative Commons BY-NC license
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    Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents

    L. M. Randolph, C. L. M. LeGuyader, M. E. Hahn, C. M. Andolina, J. P. Patterson, R. F. Mattrey, J. E. Millstone, M. Botta, M. Scadeng and N. C. Gianneschi, Chem. Sci., 2016, 7, 4230
    DOI: 10.1039/C6SC00342G

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