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Chemical Science

For findings of exceptional significance from across the chemical sciences
All articles free to read, free to publish* from 2015
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Edge Article

A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis

W. Tao,a   M. E. Yurkovich,b   S. Wen,a   K. E. Lebe,b   M. Samborskyy,b   Y. Liu,a   A. Yang,a   Y. Liu,a   Y. Ju,a   Z. Deng,a   M. Tosin,c   Y. Sun*a and   P. F. Leadlay*b  
*
Corresponding authors
a
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, People's Republic of China
E-mail: yhsun@whu.edu.cn
b
Department of Biochemistry, University of Cambridge, Sanger Building, 80 Tennis Court Road, Cambridge CB2 1GA, UK
E-mail: pfl10@cam.ac.uk
c
Department of Chemistry, University of Warwick, Library Road, Coventry CV4 7AL, UK
Chem. Sci., 2016,7, 376-385

DOI: 10.1039/C5SC03059E
Received 17 Aug 2015, Accepted 06 Oct 2015
First published online 08 Oct 2015
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Open Access
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