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Issue 6, 2016
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Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform

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Abstract

Synthesis chemistry need not be limited to either only batch or only flow; rather, in the future we expect that it will consist of an amalgamation of the best and most appropriate methods. We have therefore devised a single reactor platform to conduct both batch and flow reactions, either singly or in concert, using open source technologies to automate, control and monitor individual processes. We illustrate this concept with the multistep synthesis of 5-methyl-4-propylthiophene-2-carboxylic acid to showcase the utility of this approach in a telescoped manner. Automated downstream processing techniques, consisting of continuous extraction and solvent switching steps, were also included, further freeing the chemist from routine laboratory tasks.

Graphical abstract: Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform

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Publication details

The article was received on 07 Sep 2016, accepted on 23 Sep 2016 and first published on 30 Sep 2016


Article type: Paper
DOI: 10.1039/C6RE00160B
Citation: React. Chem. Eng., 2016,1, 629-635
  • Open access: Creative Commons BY license
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    Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform

    D. E. Fitzpatrick and S. V. Ley, React. Chem. Eng., 2016, 1, 629
    DOI: 10.1039/C6RE00160B

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