Jump to main content
Jump to site search

Issue 6, 2016
Previous Article Next Article

Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries

Author affiliations

Abstract

Molecular oxygen is without doubt the greenest oxidant for redox reactions, yet aerobic oxidation is one of the most challenging to perform with good chemoselectivity, particularly on an industrial scale. This collaborative review (between teams of chemists and chemical engineers) describes the current scientific and operational hurdles that prevent the utilisation of aerobic oxidation reactions for the production of speciality chemicals and active pharmaceutical ingredients (APIs). The safety aspects of these reactions are discussed, followed by an overview of (continuous flow) reactors suitable for aerobic oxidation reactions that can be applied on scale. Some examples of how these reactions are currently performed in the industrial laboratory (in batch and in flow) are presented, with particular focus on the scale-up strategy. Last but not least, further challenges and future perspectives are presented in the concluding remarks.

Graphical abstract: Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 30 Aug 2016, accepted on 13 Sep 2016 and first published on 22 Sep 2016


Article type: Review Article
DOI: 10.1039/C6RE00155F
Citation: React. Chem. Eng., 2016,1, 595-612
  • Open access: Creative Commons BY license
  •   Request permissions

    Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries

    A. Gavriilidis, A. Constantinou, K. Hellgardt, K. K. (. Hii, G. J. Hutchings, G. L. Brett, S. Kuhn and S. P. Marsden, React. Chem. Eng., 2016, 1, 595
    DOI: 10.1039/C6RE00155F

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author