Jump to main content
Jump to site search

Issue 5, 2016
Previous Article Next Article

Fast colorimetric screening for visible light photocatalytic oxidation and reduction reactions

Author affiliations

Abstract

Fast screening accelerates the discovery and optimization of chemical reactions. Here, we present the parallel irradiation and evaluation of 96 visible light photocatalytic reactions in a microtiter plate. After completion, a chemical indicator is added, allowing the spectroscopic determination of the formed stoichiometric by-products. Their quantity correlates in many cases with the conversion of starting materials and yield of photochemical reaction products. We demonstrate the concept with known photooxidations of organic compounds by riboflavin tetraacetate (RFTA) and reproduce published results and gas chromatographic analyses by a colorimetric assay. Two new photocatalysts for the hydroxylation of boronic acids and new substrates for the photocatalytic generation of aryl radicals from aryl halides were identified. By screening a series of drug molecules containing aryl halides, new photochemical dehalogenation reactions were found. The presented methods enable laboratories lacking sophisticated high-throughput analytical instrumentation to perform parallel optimization and scope determination of photocatalytic oxidation and reduction reactions.

Graphical abstract: Fast colorimetric screening for visible light photocatalytic oxidation and reduction reactions

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Jun 2016, accepted on 25 Jul 2016 and first published on 05 Aug 2016


Article type: Paper
DOI: 10.1039/C6RE00117C
Citation: React. Chem. Eng., 2016,1, 494-500
  • Open access: Creative Commons BY license
  •   Request permissions

    Fast colorimetric screening for visible light photocatalytic oxidation and reduction reactions

    M. Poznik and B. König, React. Chem. Eng., 2016, 1, 494
    DOI: 10.1039/C6RE00117C

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements