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Reaction Chemistry & Engineering

Bridging the gap between chemistry and chemical engineering
Free access for 2016 and 2017


Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor

Corresponding authors
Institute of Process Research and Development, School of Chemistry, University of Leeds, Leeds, UK
E-mail: r.a.bourne@leeds.ac.uk
Department of Chemistry, Faraday Building, Lancaster University, Lancaster, UK
School of Chemical and Process Engineering, University of Leeds, Leeds, UK
AstraZeneca Pharmaceutical Development, Silk Road Business Park, Macclesfield, UK
React. Chem. Eng., 2016,1, 366-371

DOI: 10.1039/C6RE00059B
Received 17 Mar 2016, Accepted 05 May 2016
First published online 24 May 2016
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Open Access
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Supplementary Info