Jump to main content
Jump to site search

Issue 1, 2016
Previous Article Next Article

A convenient numbering-up strategy for the scale-up of gas–liquid photoredox catalysis in flow

Author affiliations

Abstract

Visible-light photocatalysis is a mild activation method for small molecules and enables a wide variety of transformations relevant for organic synthetic chemistry. However, one of the limitations of photocatalysis and photochemistry in general is the limited scalability due to the absorption of light (Lambert–Beer law). Here, we report the development of a convenient numbering-up strategy for the scale-up of gas–liquid photocatalytic reactions in which the gas is consumed. Only commercially available constituents were used and the system can be rapidly assembled by any practitioner of flow chemistry. The modular design allows us to systematically scale the photochemistry within 2n parallel reactors (herein, n = 0, 1, 2, 3). The flow distribution in the absence of reactions was excellent, showing a standard deviation less than 5%. Next, we used the numbered-up photomicroreactor assembly to enable the scale-up of the photocatalytic aerobic oxidation of thiols to disulfides. The flow distribution was again very good with a standard deviation lower than 10%. The yield of the target disulfide in the numbered-up assemblies was comparable to the results obtained in a single device demonstrating the feasibility of our approach.

Graphical abstract: A convenient numbering-up strategy for the scale-up of gas–liquid photoredox catalysis in flow

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 01 Sep 2015, accepted on 05 Oct 2015, published on 04 Nov 2015 and first published online on 04 Nov 2015


Article type: Paper
DOI: 10.1039/C5RE00021A
Citation: React. Chem. Eng., 2016,1, 73-81
  •   Request permissions

    A convenient numbering-up strategy for the scale-up of gas–liquid photoredox catalysis in flow

    Y. Su, K. Kuijpers, V. Hessel and T. Noël, React. Chem. Eng., 2016, 1, 73
    DOI: 10.1039/C5RE00021A

Search articles by author