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Issue 103, 2016
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Biocompatible titanate nanotubes with high loading capacity of genistein: cytotoxicity study and anti-migratory effect on U87-MG cancer cell lines

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Abstract

Titanate nanotubes (Ti-Nts) have proved to be a potential candidate for drug delivery due to their large surface change and higher cellular uptake as a direct consequence of their tubular shape. Ti-Nts were assessed for their safety, their kinetics of cellular uptake on U87-MG cell line and for genistein loading efficiency. No cytotoxic effect was observed under higher empty Ti-Nts concentrations up to 100 μg mL−1. The multiwalled tubular morphology was found to be an important parameter promoting high drug loading. The Ti-Nts could achieve higher genistein drug-loading content (25.2%) and entrapment efficiency (51.2%) leading to a controlled drug release as well as a higher cellular uptake of genistein-loaded-Ti-Nts which induces higher cytotoxicity and significant anti-migratory effect on U87-MG human glioblastoma astrocytoma, promising efficient antitumor activity.

Graphical abstract: Biocompatible titanate nanotubes with high loading capacity of genistein: cytotoxicity study and anti-migratory effect on U87-MG cancer cell lines

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Publication details

The article was received on 02 Oct 2016, accepted on 19 Oct 2016, published on 19 Oct 2016 and first published online on 19 Oct 2016


Article type: Paper
DOI: 10.1039/C6RA24569B
Citation: RSC Adv., 2016,6, 101688-101696
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    Biocompatible titanate nanotubes with high loading capacity of genistein: cytotoxicity study and anti-migratory effect on U87-MG cancer cell lines

    T. Baati, B. B. Kefi, A. Aouane, L. Njim, F. Chaspoul, V. Heresanu, A. Kerkeni, F. Neffati and M. Hammami, RSC Adv., 2016, 6, 101688
    DOI: 10.1039/C6RA24569B

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