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Issue 103, 2016
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A facile and highly chemoselective synthesis of 1-thia-3a,6-diaza-benzo[e]azulen-3-ones by 7-exo-dig/trig halocyclizations

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Abstract

This manuscript describes a study on relatively unexplored halogen mediated 7-exo-dig/trig cyclization reactions of 2-(2-amino-aryl)-3-prop-2-ynyl/allyl-thiazolidin-4-ones for the formation of thiazole condensed 1,4-benzodiazepines in good yields. The reactions are facile, chemoselective and involve the use of simple substrates leading to synthesis of diversely functionalized 1,4-benzodiazepines. The synthesis of such condensed 1,4-benzodiazepines is important in terms of their usefulness as biological active agents.

Graphical abstract: A facile and highly chemoselective synthesis of 1-thia-3a,6-diaza-benzo[e]azulen-3-ones by 7-exo-dig/trig halocyclizations

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Publication details

The article was received on 21 Sep 2016, accepted on 15 Oct 2016 and first published on 17 Oct 2016


Article type: Communication
DOI: 10.1039/C6RA23493C
Citation: RSC Adv., 2016,6, 101587-101591
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    A facile and highly chemoselective synthesis of 1-thia-3a,6-diaza-benzo[e]azulen-3-ones by 7-exo-dig/trig halocyclizations

    B. Kuila, D. Mahajan, P. Singh and G. Bhargava, RSC Adv., 2016, 6, 101587
    DOI: 10.1039/C6RA23493C

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