Jump to main content
Jump to site search

Issue 104, 2016, Issue in Progress
Previous Article Next Article

A new trick (hydroxyl radical generation) of an old vitamin (B2) for near-infrared-triggered photodynamic therapy

Author affiliations

Abstract

The photosensitizer has been supposed to be the key component in photodynamic therapy (PDT). Natural products and their intricate molecular frameworks are often used as starting points for drug discovery. Riboflavin (RF), also known as vitamin B2, has a unique conjugate structure of an isoalloxazine ring, and is a potential photosensitizer for use in the PDT of cancers. In this study, a novel near-infrared (NIR) mediated nanocomposite for PDT is presented, using this old vitamin (RF) as a PDT photosensitizer, integrated with the upconversion nanotechnology. Mesoporous silica coated sodium yttrium fluoride:ytterbium/thulium (NaYF4:Yb/Tm) nanoparticles were fabricated and used as drug carriers and photo-transducers. Chemical modification of RF was performed to obtain a photostable photosensitizer, 2′,3′,4′,5′-tetraacetylriboflavin (RTA). There is a good overlap between the fluorescence emission of NaYF4:Yb/Tm nanoparticles and the UV-visible absorption of RTA. The RTA molecules were incorporated into the mesoporous silica shell and the fluorescent emission from the NaYF4:Yb/Tm nanoparticles can be absorbed by RTA molecules under NIR irradiation. NIR-initiated reactive oxygen species generation was validated using electron paramagnetic resonance (EPR) spectroscopy combined with spin trapping. The results from the in vitro cell test show that this nanocomposite has good photodynamic efficacy. All the chemicals involved in this process are non-toxic, environmentally benign, and easily available. Thus, this nanocomposite has great potential in PDT applications.

Graphical abstract: A new trick (hydroxyl radical generation) of an old vitamin (B2) for near-infrared-triggered photodynamic therapy

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 21 Sep 2016, accepted on 15 Oct 2016, published on 17 Oct 2016 and first published online on 17 Oct 2016


Article type: Paper
DOI: 10.1039/C6RA23440B
Citation: RSC Adv., 2016,6, 102647-102656
  •   Request permissions

    A new trick (hydroxyl radical generation) of an old vitamin (B2) for near-infrared-triggered photodynamic therapy

    F. Xu, J. Li, T. Zhu, S. Yu, C. Zuo, R. Yao and H. Qian, RSC Adv., 2016, 6, 102647
    DOI: 10.1039/C6RA23440B

Search articles by author