Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 103, 2016, Issue in Progress
Previous Article Next Article

Near-infrared cyanine-based sensor for Fe3+ with high sensitivity: its intracellular imaging application in colorectal cancer cells

Author affiliations

Abstract

The ability to sense iron ions (Fe3+) has attracted considerable attention because of the crucial role that Fe3+ plays in a variety of vital cell functions. In this article, two novel near-infrared (NIR) cyanine-based compounds CAM and CAT bearing specific binding functional groups were developed for the detection of iron ions (Fe3+). Intriguingly, compared with CAT, only CAM with an N-(2-hydroxyethyl)acetamide group as the receptor can recognize the Fe3+ ion with high selectivity and sensitivity. The “naked-eye” color change from pea green to deep blue enables CAM to act as a highly efficient colorimetric sensor for the Fe3+ ion. Moreover, the unique NIR fluorescence response of CAM with Fe3+ was also observed in the presence of other competitive transition metal ions or cellular cations. Finally, CAM, with its excellent membrane permeability, was successfully applied for monitoring Fe3+ in colorectal cancer cells by fluorescence microscopy. This work offers a convenient colorimetric and fluorometric NIR Fe3+-selective probe based on the modification of typical tricarbocyanines, and cell imaging studies demonstrate that this sensor is capable of intracellular sensing of Fe3+ in living colorectal cancer cells, and eventually whole organisms.

Graphical abstract: Near-infrared cyanine-based sensor for Fe3+ with high sensitivity: its intracellular imaging application in colorectal cancer cells

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 14 Sep 2016, accepted on 12 Oct 2016 and first published on 13 Oct 2016


Article type: Paper
DOI: 10.1039/C6RA22966B
Citation: RSC Adv., 2016,6, 100759-100764
  •   Request permissions

    Near-infrared cyanine-based sensor for Fe3+ with high sensitivity: its intracellular imaging application in colorectal cancer cells

    M. Zhu, C. Shi, X. Xu, Z. Guo and W. Zhu, RSC Adv., 2016, 6, 100759
    DOI: 10.1039/C6RA22966B

Search articles by author