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Issue 104, 2016, Issue in Progress
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Promising ESIPT-based fluorescence sensor for Cu2+ and CN ions: investigation towards logic gate behaviour, anticancer activities and bioimaging application

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Abstract

An excited state intramolecular proton transfer (ESIPT) process-based novel chromogenic and fluorogenic probe (2) was synthesized with the aim of sequential in situ detection of Cu2+ and CN ions under aqueous and biological conditions. The probe revealed chelating affinity for transition metal cations, amidst which only Cu2+ efficiently quenches the emission intensity. Further in situ addition of CN results in a metal displacement reaction and a turn on fluorescence response. This quencher displacement sensing strategy results in “ON–OFF–ON” type of fluorescence changes with high selectivity and great affinity in nanomolar detection of [CN] and outlines the working principle of the IMPLICATION logic gate. The in vitro cytotoxic activity studied via the MTT assay revealed that in situ-formed Cu complexes worked as potential anticancer chemotherapeutic agents towards MCF-7 (human breast adenocarcinoma) cell lines (2 + Cu2+ IC50 = 5.69 ± 0.26 μg mL−1, 3 + Cu2+ IC50 = 7.36 ± 0.29 μg mL−1). The selective detection of Cu2+ and CN ions in biological systems was also explained by intracellular bioimaging studies in MCF-7 cell lines.

Graphical abstract: Promising ESIPT-based fluorescence sensor for Cu2+ and CN− ions: investigation towards logic gate behaviour, anticancer activities and bioimaging application

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Publication details

The article was received on 07 Sep 2016, accepted on 29 Sep 2016 and first published on 30 Sep 2016


Article type: Paper
DOI: 10.1039/C6RA22352D
Citation: RSC Adv., 2016,6, 102096-102101
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    Promising ESIPT-based fluorescence sensor for Cu2+ and CN ions: investigation towards logic gate behaviour, anticancer activities and bioimaging application

    S. Bhardwaj, N. Maurya, A. K. Singh, R. Varshney and P. Roy, RSC Adv., 2016, 6, 102096
    DOI: 10.1039/C6RA22352D

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