Jump to main content
Jump to site search

Issue 104, 2016, Issue in Progress
Previous Article Next Article

Efficient asymmetric biosynthesis of (R)-(−)-epinephrine in hydrophilic ionic liquid-containing systems

Author affiliations

Abstract

The strain Acinetobacter sp. UN-16 with adrenaline dehydrogenase could catalyze adrenalone to (R)-(−)-epinephrine. For the asymmetric biosynthesis of (R)-(−)-epinephrine with whole cells of Acinetobacter sp. UN-16, ten different hydrophilic ionic liquids were successfully tested. The diverse water–ionic liquid systems showed significant but different influences on the initial reaction rate, yield, and reduction activity. Of all the tested ionic liquids, [HOOCEMIM]NO3 showed good biocompatibility, moderately increased cell membrane permeability, markedly improved reaction efficiency and best biotransformation results.

Graphical abstract: Efficient asymmetric biosynthesis of (R)-(−)-epinephrine in hydrophilic ionic liquid-containing systems

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Sep 2016, accepted on 30 Sep 2016 and first published on 14 Oct 2016


Article type: Communication
DOI: 10.1039/C6RA22140H
Citation: RSC Adv., 2016,6, 102292-102295
  •   Request permissions

    Efficient asymmetric biosynthesis of (R)-(−)-epinephrine in hydrophilic ionic liquid-containing systems

    Z. Xu, Q. Wu, M. Yang, S. Wang, Z. Wang and X. Xu, RSC Adv., 2016, 6, 102292
    DOI: 10.1039/C6RA22140H

Search articles by author

Spotlight

Advertisements