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Issue 104, 2016, Issue in Progress
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Anti selective glycolate aldol reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one: application towards the asymmetric synthesis of 8-4′-oxyneolignans

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Abstract

The anti selective glycolate aldol reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one auxiliary have been standardized with high yields and excellent diastereoselectivities on various substituted aryl, allyl and alkyl aldehydes. The optimized reaction conditions were employed for the stereoselective synthesis of oxyneolignans.

Graphical abstract: Anti selective glycolate aldol reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one: application towards the asymmetric synthesis of 8-4′-oxyneolignans

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Publication details

The article was received on 02 Sep 2016, accepted on 04 Oct 2016 and first published on 14 Oct 2016


Article type: Paper
DOI: 10.1039/C6RA22026F
Citation: RSC Adv., 2016,6, 102116-102126
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    Anti selective glycolate aldol reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one: application towards the asymmetric synthesis of 8-4′-oxyneolignans

    M. Gangar, A. Ittuveetil, S. Goyal, A. Pal, Harikrishnan M. and V. A. Nair, RSC Adv., 2016, 6, 102116
    DOI: 10.1039/C6RA22026F

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