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Issue 103, 2016
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Increment of the FRET efficiency between carbon dots and photosensitizers for enhanced photodynamic therapy

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Abstract

Mg/N double-doped carbon dots (CDs) with a quantum yield up to 84.6% were synthesized by a one-step hydrothermal method, and the as-prepared CDs were then successfully used as carriers for an insoluble photosensitizer (chlorin e6, Ce6). Besides the high fluorescence quantum yield of the CDs, the short donor–acceptor distance and excessive acceptors per donor of the designed CDs–Ce6 system contributed to the high fluorescence resonance energy transfer (FRET) efficiency (up to 84%) and final enhanced photodynamic reaction. The CDs–Ce6 system showed excellent hydrophilicity and particularly tunable FRET efficiency. Its singlet oxygen (SO) quantum yield was double that of pure Ce6, and a significant photodynamic therapy (PDT) effect was proven on HepG2 cancer cells.

Graphical abstract: Increment of the FRET efficiency between carbon dots and photosensitizers for enhanced photodynamic therapy

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Publication details

The article was received on 12 Aug 2016, accepted on 09 Oct 2016 and first published on 12 Oct 2016


Article type: Paper
DOI: 10.1039/C6RA20412K
Citation: RSC Adv., 2016,6, 101447-101451
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    Increment of the FRET efficiency between carbon dots and photosensitizers for enhanced photodynamic therapy

    K. Yang, F. Li, W. Che, X. Hu, C. Liu and F. Tian, RSC Adv., 2016, 6, 101447
    DOI: 10.1039/C6RA20412K

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