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Issue 103, 2016, Issue in Progress
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Turn-on fluorescence detection of ciprofloxacin in tablets based on lanthanide coordination polymer nanoparticles

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Abstract

Metal–organic coordination polymers (MOCPs) have emerged as a new family of functional nanomaterials. Here, we report a facile and effective fluorescence method for detecting CIP in tablets using a kind of lanthanide coordination polymer nanoparticle (LCPNP), specifically Eu/GMP NPs, as the sensing platform. Eu/GMP NPs, composed of guanosine monophosphate (GMP) and europium (Eu3+) ion, are by themselves non-luminescent. The addition of ciprofloxacin (CIP) into the Eu/GMP NPs, however, noticeably enhanced their fluorescence due to the strong coordination interaction between CIP and Eu3+, and the improved hydrophobic interior of the LCPNPs resulted in an efficient energy transfer from CIP to Eu3+. The fluorescence intensity of Eu/GMP at 615 nm showed a linear relationship with CIP concentration between 1.0 and 40 μM, with a detection limit of 780 nM. We believe that the proposed time-resolved fluorometric assay based on the Eu/GMP NP lanthanide nanosensor, with its long fluorescence lifetime, has a great potential for using in the testing of biosamples.

Graphical abstract: Turn-on fluorescence detection of ciprofloxacin in tablets based on lanthanide coordination polymer nanoparticles

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Publication details

The article was received on 12 Aug 2016, accepted on 25 Sep 2016 and first published on 26 Sep 2016


Article type: Paper
DOI: 10.1039/C6RA20357D
Citation: RSC Adv., 2016,6, 100743-100747
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    Turn-on fluorescence detection of ciprofloxacin in tablets based on lanthanide coordination polymer nanoparticles

    B. Liu, Y. Huang, Q. Shen, X. Zhu, Y. Hao, P. Qu and M. Xu, RSC Adv., 2016, 6, 100743
    DOI: 10.1039/C6RA20357D

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