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Issue 102, 2016
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Cu-Catalyzed ligand-free synthesis of rosuvastatin based novel indole derivatives as potential anticancer agents

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Abstract

Rosuvastatin based novel indole derivatives designed as potential anti-cancer agents were synthesized via a newly developed ligand-free, simple, straightforward and inexpensive one-pot method. The methodology involved a Cu-catalyzed coupling-cyclization of a rosuvastatin based alkyne with o-iodoanilides in the presence of CuI and K2CO3 in PEG-400. Three of the synthesized compounds showed promising anti-proliferative activities against cancer cell lines and an increase of p21 mRNA expression and apoptotic effects in zebrafish embryos/larvae.

Graphical abstract: Cu-Catalyzed ligand-free synthesis of rosuvastatin based novel indole derivatives as potential anticancer agents

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Publication details

The article was received on 09 Aug 2016, accepted on 10 Oct 2016 and first published on 17 Oct 2016


Article type: Communication
DOI: 10.1039/C6RA20148B
Citation: RSC Adv., 2016,6, 100487-100493
  • Open access: Creative Commons BY-NC license
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    Cu-Catalyzed ligand-free synthesis of rosuvastatin based novel indole derivatives as potential anticancer agents

    K. S. Kumar, B. Rajesham, M. S. Ramulu, B. Bhaskar, S. N. Dash, M. A. Ashfaq, R. Nagarapu, A. A. Khan, S. Lehtonen and M. Pal, RSC Adv., 2016, 6, 100487
    DOI: 10.1039/C6RA20148B

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