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Issue 102, 2016, Issue in Progress
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Measurement of 1H NMR relaxation times in complex organic chemical systems: application of PSYCHE

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Abstract

Relaxation times provide a wealth of information on intramolecular dynamics and intermolecular interactions. However, in complex molecular systems with extensive peak overlaps in NMR spectra, relaxation time measurements are severely hampered due to difficulties in quantitation of peak intensities for individual protons. Here, we incorporate PSYCHE homodecoupling in inversion recovery and CPMG NMR experiments to significantly enhance spectral resolution, thereby enabling unambiguous measurement of relaxation times, T1 and T2, in two complex systems. This includes a specific application to study drug–protein interactions.

Graphical abstract: Measurement of 1H NMR relaxation times in complex organic chemical systems: application of PSYCHE

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Publication details

The article was received on 08 Aug 2016, accepted on 13 Oct 2016 and first published on 14 Oct 2016


Article type: Communication
DOI: 10.1039/C6RA20047H
Citation: RSC Adv., 2016,6, 100098-100102
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    Measurement of 1H NMR relaxation times in complex organic chemical systems: application of PSYCHE

    V. M. Rao Kakita, V. K. Shukla, M. Bopardikar, T. Bhattacharya and Ramakrishna V. Hosur, RSC Adv., 2016, 6, 100098
    DOI: 10.1039/C6RA20047H

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