Jump to main content
Jump to site search

Issue 102, 2016
Previous Article Next Article

Soluble silicon patterns and templates: calcium phosphate nanocrystal deposition in collagen type 1

Author affiliations

Abstract

Patterned mineralisation is a feature of many hard-tissues. The impressive mechanical properties exhibited by such tissues can be, in part, attributed to the patterned deposition of mineral within the organic matrix. Although not thermodynamically favourable, the deposition of calcium phosphate based mineral within collagen fibres occurs in vivo in bone and dentine. As a consequence, numerous researchers have investigated how matrix proteins may be conditioned to enable patterned mineral deposition to recapitulate the structures found in nature. In this study, we have demonstrated that this patterned mineralisation of collagen type I may be induced simply by the pretreatment of the collagen with orthosilicic acid (OSA). The OSA treatment of the collagen resulted in a structural change to the collagen fibres, modifying the fibril diameter and changing the kinetics of fibre formation. NMR demonstrated that the OSA was preferentially located at the termini of the procollagen fibrils, thereby templating the formation of apatitic calcium phosphate crystals within the collagen fibrils (as shown using TEM, EDX and SAED). This work demonstrates how simple inorganic ions can have potent effects on structuring biological precipitates and suggests why trace quantities of silicon ions are essential to the formation of healthy hard tissues.

Graphical abstract: Soluble silicon patterns and templates: calcium phosphate nanocrystal deposition in collagen type 1

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Aug 2016, accepted on 27 Sep 2016 and first published on 11 Oct 2016


Article type: Paper
DOI: 10.1039/C6RA19784A
Citation: RSC Adv., 2016,6, 99809-99815
  • Open access: Creative Commons BY license
  •   Request permissions

    Soluble silicon patterns and templates: calcium phosphate nanocrystal deposition in collagen type 1

    G. Birdi-Chouhan, R. M. Shelton, J. Bowen, P. Goldberg-Oppenheimer, S. J. Page, J. V. Hanna, A. Peacock, A. J. Wright and L. M. Grover, RSC Adv., 2016, 6, 99809
    DOI: 10.1039/C6RA19784A

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements