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Issue 105, 2016, Issue in Progress
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Cationic porphyrin@SPION nanospheres as multifunctional anticancer therapeutics: magnetic targeting, photodynamic potential and bio-safety research

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Abstract

The synthesis and characterization of carboxyl-functionalized superparamagnetic iron oxide nanoparticles (SPION)-attached cationic porphyrins with different positive charges (porphyrin@SPION) are described as pH-sensitive, multifunctional photosensitization. These nanospheres exhibit excellent targeted cell accumulation under external magnetic field and outstanding cell photocytotoxicity in weak acidic solution, which is the pH for most tumors. The dicationic porphyrin@SPION has the smartest pH-responding release and lowest half-maximal inhibitory concentration (IC50) values after visible light irradiation against HeLa cells. Moreover, the delivery safety of these porphyrin@SPION nanospheres was considered by investigating their behaviors in human plasma during the delivery process. The results elucidate that these nanospheres have no significant deleterious influence on the frame conformation of protein in their delivery process and thus are relatively safe in the drug delivery process. Our study demonstrates that the combination of targeted magnetic-loading drug design methodology with the PDT potential of cationic porphyrins may be a very useful strategy to develop novel tumor-oriented multifunctional anticancer therapeutics.

Graphical abstract: Cationic porphyrin@SPION nanospheres as multifunctional anticancer therapeutics: magnetic targeting, photodynamic potential and bio-safety research

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Publication details

The article was received on 04 Aug 2016, accepted on 09 Oct 2016 and first published on 14 Oct 2016


Article type: Paper
DOI: 10.1039/C6RA19697G
Citation: RSC Adv., 2016,6, 103137-103148
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    Cationic porphyrin@SPION nanospheres as multifunctional anticancer therapeutics: magnetic targeting, photodynamic potential and bio-safety research

    P. Zhao, M. Liu, Thushara W. Madanayake, C. Reena, M. Zheng, Z. Cheng, Y. Huang and X. Wang, RSC Adv., 2016, 6, 103137
    DOI: 10.1039/C6RA19697G

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