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Issue 103, 2016
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A benchtop NMR spectrometer as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four organic transformations

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Abstract

An approach is reported for monitoring continuous-flow reactions by means of a low-field benchtop NMR spectrometer. The spectrometer is interfaced with a mesofluidic reactor and used as a tool for optimising four organic transformations, namely an acid-catalysed esterification, a Knoevenagel condensation, a Diels–Alder reaction, and an alkylation. Reactions need to be performed either solvent-free or at relatively high concentration in order to monitor them effectively using the NMR spectrometer, but this allows for the leveraging of one of the key advantages of flow processing, namely process intensification.

Graphical abstract: A benchtop NMR spectrometer as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four organic transformations

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Publication details

The article was received on 03 Aug 2016, accepted on 12 Oct 2016, published on 13 Oct 2016 and first published online on 13 Oct 2016


Article type: Paper
DOI: 10.1039/C6RA19662D
Citation: RSC Adv., 2016,6, 101171-101177
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    A benchtop NMR spectrometer as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four organic transformations

    C. M. Archambault and N. E. Leadbeater, RSC Adv., 2016, 6, 101171
    DOI: 10.1039/C6RA19662D

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