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Issue 90, 2016, Issue in Progress
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A turn-on dual emissive nucleobase sensitive to mismatches and duplex conformational changes

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Abstract

Herein, a 2-furyl-3-hydroxychromone-based deoxyuridine analogue was synthesized and incorporated into DNA. Its ESIPT mechanism, investigated by steady-state and time-resolved spectroscopy, was found to be highly sensitive to hydration through its ratiometric response. As a result, this analogue demonstrated a unique on–off dual emissive behavior which allows monitoring DNA hybridization as well as discriminating matched from mismatched duplexes, and B from A conformations.

Graphical abstract: A turn-on dual emissive nucleobase sensitive to mismatches and duplex conformational changes

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Publication details

The article was received on 27 Jul 2016, accepted on 07 Sep 2016 and first published on 07 Sep 2016


Article type: Communication
DOI: 10.1039/C6RA19061H
Citation: RSC Adv., 2016,6, 87142-87146
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    A turn-on dual emissive nucleobase sensitive to mismatches and duplex conformational changes

    K. Gavvala, N. P. F. Barthes, D. Bonhomme, A. S. Dabert-Gay, D. Debayle, B. Y. Michel, A. Burger and Y. Mély, RSC Adv., 2016, 6, 87142
    DOI: 10.1039/C6RA19061H

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