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Issue 102, 2016, Issue in Progress
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Facile synthesis of novel hydrophilic and carboxyl-amine functionalized superparamagnetic iron oxide nanoparticles for biomedical applications

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Abstract

In this work, we aim to synthesize water soluble and surface functionalized superparamagnetic iron oxide nanoparticles (SPIONs) using novel surfactants such as terephthalic acid (TA), 2-aminoterephthalic acid (ATA), trimesic acid (TMA) and pyromellitic acid (PMA) through one-step facile chemical co-precipitation and thermal decomposition methods. The as-synthesized SPIONs are characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering (DLS) measurements, Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and vibrating sample magnetometer (VSM). The as-synthesized SPIONs showed very good water solubility and a high magnetization value (Ms = 55–73 emu g−1). Furthermore, the as-synthesized ATA-coated SPIONs are conjugated with a fluorophore (Alexa Fluor 488) to demonstrate their ability for further chemical/biological conjugation without any additional surface modifications. Moreover, above 90% cell viability in MCF-7 cancer cells has been observed, thus confirming good cytocompatibility of the SPIONs. Therefore, these hydrophilic and carboxyl-amine functionalized SPIONs are very promising candidates to be used for biomedical applications.

Graphical abstract: Facile synthesis of novel hydrophilic and carboxyl-amine functionalized superparamagnetic iron oxide nanoparticles for biomedical applications

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Publication details

The article was received on 21 Jul 2016, accepted on 07 Oct 2016 and first published on 14 Oct 2016


Article type: Paper
DOI: 10.1039/C6RA18567C
Citation: RSC Adv., 2016,6, 99948-99959
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    Facile synthesis of novel hydrophilic and carboxyl-amine functionalized superparamagnetic iron oxide nanoparticles for biomedical applications

    G. Kandasamy, S. Surendran, A. Chakrabarty, S. N. Kale and D. Maity, RSC Adv., 2016, 6, 99948
    DOI: 10.1039/C6RA18567C

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