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Issue 103, 2016
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A novel diagnostic method of Raman spectroscopy for malignant pheochromocytoma/paraganglioma

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Abstract

We evaluated the feasibility of Raman spectroscopy in the diagnosis of malignant pheochromocytoma/paraganglioma. Raman spectra were detected from pheochromocytoma/paraganglioma tissues using a Labram HR 800 RS, then principal component analysis and linear discriminant analysis were applied to prediction. There are 25 qualified patients, including 20 with benign pheochromocytoma/paraganglioma and 5 with malignant pheochromocytoma/paraganglioma. The spectra at 680, 733, 780, 847, 939, 993, 1049, 1121, 1170, 1222, 1268, 1314, 1370, 1433, 1487, 1615, 1757 cm−1 of benign and malignant pheochromocytoma/paraganglioma are significantly different, assigned to specific amino acids and DNA. Principal component analysis/linear discriminant analysis yielded a sensitivity of 80.0% and a specificity of 100.0% for diagnosing malignant pheochromocytoma/paraganglioma. Furthermore, we evaluated the malignant behavior of pheochromocytoma/paraganglioma by both Raman spectroscopy and PASS scale. By using a survival analysis, Raman spectroscopy became more efficient than PASS score. Finally, Raman spectroscopy has potential in the diagnosis of malignant pheochromocytoma/paraganglioma in clinical practice.

Graphical abstract: A novel diagnostic method of Raman spectroscopy for malignant pheochromocytoma/paraganglioma

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Publication details

The article was received on 18 Jul 2016, accepted on 09 Oct 2016 and first published on 18 Oct 2016


Article type: Paper
DOI: 10.1039/C6RA18312C
Citation: RSC Adv., 2016,6, 101178-101184
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    A novel diagnostic method of Raman spectroscopy for malignant pheochromocytoma/paraganglioma

    Y. Du, Z. Huang, L. Wang, L. Huang, P. Cao, D. He, Y. zhang, D. Wu, Z. Yang and J. Fan, RSC Adv., 2016, 6, 101178
    DOI: 10.1039/C6RA18312C

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