Issue 85, 2016, Issue in Progress

One-step synthesis of imidazo[1,2-a]pyridines in water

Abstract

A novel straightforward method for the synthesis of 2,3-disubstituted imidazo[1,2-a]pyridine derivatives in water as a truly safe and cheap reaction medium was developed. Hence, N-alkyl pyridinium and S-alkyl thiouronium salts were reacted in the presence of NaHCO3 as a mild base in water to produce imidazo[1,2-a]pyridines in moderate to excellent yields.

Graphical abstract: One-step synthesis of imidazo[1,2-a]pyridines in water

Supplementary files

Article information

Article type
Paper
Submitted
03 Jul 2016
Accepted
19 Aug 2016
First published
23 Aug 2016

RSC Adv., 2016,6, 81943-81949

One-step synthesis of imidazo[1,2-a]pyridines in water

H. Zali-Boeini, N. Norastehfar and H. Amiri Rudbari, RSC Adv., 2016, 6, 81943 DOI: 10.1039/C6RA17065J

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