Trifluoromethylation of haloarenes with a new trifluoro-methylating reagent Cu(O2CCF2SO2F)2

Abstract

A new trifluoromethylating reagent Cu(O₂CCF₂SO₂F)₂, which easily decomposes to generate active CuCF₃ species in DMF at room temperature, has been conveniently prepared from inexpensive starting materials on a large scale. This new reagent can be applied to efficiently trifluoromethylate a variety of haloarenes under mild conditions, providing good-to-excellent yields of the desired products.