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Issue 52, 2016
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Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries

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Abstract

A tandem Mannich/Diels–Alder sequence for the synthesis of small-molecule libraries with an indolyl-octahydro-3a,6-epoxy-isoindole core structure is demonstrated in this study. Representative diversification examples based on this scaffold were performed, and a library is being produced within the European Lead Factory (ELF) Consortium.

Graphical abstract: Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries

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Publication details

The article was received on 05 Apr 2016, accepted on 02 May 2016 and first published on 05 May 2016


Article type: Communication
DOI: 10.1039/C6RA08786H
Citation: RSC Adv., 2016,6, 46654-46657
  • Open access: Creative Commons BY-NC license
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    Tandem Mannich/Diels–Alder reactions for the synthesis of indole compound libraries

    P. Wu, M. Å. Petersen, R. Petersen, T. Flagstad, R. Guilleux, M. Ohsten, R. Morgentin, T. E. Nielsen and M. H. Clausen, RSC Adv., 2016, 6, 46654
    DOI: 10.1039/C6RA08786H

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